abstract：BACKGROUND AND AIM:Rejection of liver grafts is a difficult issue that has not been resolved. Preoperative replacement of liver cells in the graft with cells from the intended recipient may attenuate rejection. We investigated whether preoperative transplant of recipient bone marrow cells (BMCs) to the donor replaced l...

journal_title：Journal of gastroenterology and hepatology

authors： Endo K,Hori T,Jobara K,Hata T,Tsuruyama T,Uemoto S

更新日期：2015-05-01 00:00:00

abstract：:Barrett's esophagus (BE), a common condition, is the only known precursor to esophageal adenocarcinoma (EAC). There is uncertainty about the best way to manage BE as most people with BE never develop EAC and most patients diagnosed with EAC have no preceding diagnosis of BE. Moreover, there have been recent advances i...

journal_title：Journal of gastroenterology and hepatology

authors： Whiteman DC,Appleyard M,Bahin FF,Bobryshev YV,Bourke MJ,Brown I,Chung A,Clouston A,Dickins E,Emery J,Eslick GD,Gordon LG,Grimpen F,Hebbard G,Holliday L,Hourigan LF,Kendall BJ,Lee EY,Levert-Mignon A,Lord RV,Lord SJ

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AND AIM:In Crohn's disease (CD), assessment of disease activity and extension is important for clinical management. Endoscopy is the most reliable tool for evaluating disease activity in these patients and it distinguishes between lesions based on ulcer, erosion, and redness. Magnetic resonance imaging (MRI)...

journal_title：Journal of gastroenterology and hepatology

authors： Sato H,Tamura C,Narimatsu K,Shimizu M,Takajyo T,Yamashita M,Inoue Y,Ozaki H,Furuhashi H,Maruta K,Yasutake Y,Yoshikawa K,Watanabe C,Komoto S,Tomita K,Nagao S,Miura S,Shinmoto H,Hokari R

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND AIM:Data about the efficacy of de novo combination therapies, or optimization strategy by adding the other drug based on the virological response at week 24 of low genetic barrier antiviral agents is still limited. This study aimed to compare the efficacy at week 104 of lamivudine monotherapy (MONO), lam...

journal_title：Journal of gastroenterology and hepatology

authors： Liang X,Cheng J,Sun Y,Chen X,Li T,Wang H,Jiang J,Chen X,Long H,Tang H,Yu Y,Sheng J,Chen S,Niu J,Ren H,Shi J,Dou X,Wan M,Jiang J,Xie Q,Shi G,Ning Q,Chen C,Tan D,Ma H,Sun J,Jia J,Zhuang H,Hou J

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Absolute lymphocyte count (ALC) and the recovery of ALC after treatment have been identified as a prognostic biomarker for several malignancies. In this study, we aimed to investigate the prognostic role of peritransplant ALC and ALC recovery after liver transplantation (LT) in hepatocellular carcin...

journal_title：Journal of gastroenterology and hepatology

authors： Zheng Z,Lin B,Zhang J,Yang Z,Xie H,Zhou L,Zhang M,Zheng S

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND AIM:Endoscopic assessment of mucosal healing in ulcerative colitis (UC) is increasingly accepted as a measure of disease activity, therapeutic goal, and the key prognostic indicator. While regular endoscopy evaluates appearance of the mucosal surface, confocal laser endomicroscopy (CLE) enables in vivo v...

journal_title：Journal of gastroenterology and hepatology

authors： Macé V,Ahluwalia A,Coron E,Le Rhun M,Boureille A,Bossard C,Mosnier JF,Matysiak-Budnik T,Tarnawski AS

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND AND AIM:This prospective pilot study investigated whether it is possible to predict the therapeutic response in both the early phase (1 week) and sustained phase (4 weeks) before starting proton pump inhibitor (PPI) therapy for functional dyspepsia (FD) or non-erosive reflux disease (NERD). METHODS:We admin...

journal_title：Journal of gastroenterology and hepatology

authors： Nagahara A,Miwa H,Asaoka D,Shimada Y,Sasaki H,Matsumoto K,Osada T,Hojo M,Watanabe S

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND AND AIM:Oral mucosal pathologies are frequent in inflammatory bowel disease (IBD). Since host-microbiome interactions are implicated in the pathogenesis of IBD, in this study the potential for changes affecting the oral microbiome was evaluated using two complementary mouse models of colitis: either chemical...

journal_title：Journal of gastroenterology and hepatology

authors： Rautava J,Pinnell LJ,Vong L,Akseer N,Assa A,Sherman PM

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Data on risk of hepatocellular carcinoma (HCC) in patients with Wilson disease are scarce. We determine HCC risk in a well-defined cohort of Wilson patients. METHODS:All patients with a confirmed diagnosis of Wilson disease (Leipzig score ≥ 4) in three Dutch university referral hospitals were inclu...

journal_title：Journal of gastroenterology and hepatology

authors： van Meer S,de Man RA,van den Berg AP,Houwen RH,Linn FH,van Oijen MG,Siersema PD,van Erpecum KJ

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND AND AIMS:The clinical significance and prognosis of mixed adenocarcinoma in early gastric cancer (EGC) are incompletely understood. The aim of this study was to evaluate the clinicopathological characteristics and long-term outcomes of mixed adenocarcinoma diagnosed as EGC after endoscopic submucosal dissect...

journal_title：Journal of gastroenterology and hepatology

authors： Han JP,Hong SJ,Kim HK

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND AIM:Studies focused on the naturally occurring resistance mutation rate in treatment-naïve chronic hepatitis B (CHB) patients have set off a furious dispute. We conduct this meta-analysis to appraise the pooled incidence of spontaneous hepatitis B virus resistance mutations worldwide and its distribution...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang Q,Liao Y,Cai B,Li Y,Li L,Zhang J,An Y,Wang L

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND AIM:The vaccination against hepatitis B virus (HBV) is recommended in patients with inflammatory bowel disease (IBD). However, the response to this vaccine seems to be lower in IBD patients than in the general population. This study aims to evaluate the immunogenicity of the HBV vaccine in a cohort of pa...

journal_title：Journal of gastroenterology and hepatology

authors： Cossio-Gil Y,Martínez-Gómez X,Campins-Martí M,Rodrigo-Pendás JÁ,Borruel-Sainz N,Rodríguez-Frías F,Casellas-Jordà F

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND AIM:Dendritic cells (DCs) are observed on the Helicobacter pylori-infected gastric mucosa. DCs generally play an important role in the regulation of inflammation. Although stimulation of gastric epithelial cells with H. pylori vacuolating cytotoxin (VacA) has been reported to induce apoptosis and endopla...

journal_title：Journal of gastroenterology and hepatology

authors： Kim JM,Kim JS,Kim N,Ko SH,Jeon JI,Kim YJ

更新日期：2015-01-01 00:00:00

abstract：:Acid-sensing pathways, which trigger mucosal defense mechanisms in response to luminal acid, involve the rapid afferent-mediated "capsaicin pathway" and the sustained "prostaglandin (PG) pathway." Luminal acid quickly increases protective PG synthesis and release from epithelia, although the mechanism by which luminal...

journal_title：Journal of gastroenterology and hepatology

authors： Akiba Y,Kaunitz JD

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND AIM:Helicobacter pylori (H. pylori) infection is a strong risk factor for the development of gastric cancer. In 2013, the Japanese government approved H. pylori eradication therapy in patients with chronic gastritis as well as peptic ulcer. However, the continuing decline in eradication rates for first-l...

journal_title：Journal of gastroenterology and hepatology

authors： Kawai T,Takahashi S,Suzuki H,Sasaki H,Nagahara A,Asaoka D,Matsuhisa T,Masaoaka T,Nishizawa T,Suzuki M,Ito M,Kurihara N,Omata F,Mizuno S,Torii A,Kawakami K,Ohkusa T,Tokunaga K,Mine T,Sakaki N

更新日期：2014-12-01 00:00:00

abstract：:There are over 500-750 000 deaths per year because of hepatitis B virus (HBV)-related cirrhosis and liver cancer worldwide and the World Health Organization Western Pacific Region has some of the highest endemic levels of HBV in the world, particularly within China, South East Asia and Pacific Island Countries and Ter...

journal_title：Journal of gastroenterology and hepatology

authors： Howell J,Van Gemert C,Lemoine M,Thursz M,Hellard M

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Acute graft-versus-host disease (GVHD) occurring within 100 days post-transplant is one of critical factors influencing prognosis in transplant recipients. Among cases of GVHD of the gastrointestinal (GI) tract, GVHD rarely affects the upper GI. In this study, we retrospectively examined the frequen...

journal_title：Journal of gastroenterology and hepatology

authors： Nomura K,Iizuka T,Kaji D,Yamamoto H,Kuribayashi Y,Kimura R,Yamada A,Furuhata T,Yamashita S,Kikuchi D,Matsui A,Mitani T,Ogawa O,Hoteya S,Ota Y,Taniguchi S,Kaise M

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AND AIM:This study aimed to evaluate the outcomes and toxicities of repeated stereotactic ablative radiotherapy (SABR) in hepatocellular carcinoma (HCC). METHODS:Fourteen HCC patients with local recurrence (18 lesions) after liver SABR received repeated radiotherapy with SABR using CyberKnife. No patients e...

journal_title：Journal of gastroenterology and hepatology

authors： Lo CH,Huang WY,Lin KT,Lin MJ,Lin TP,Jen YM

更新日期：2014-11-01 00:00:00

abstract：:Biliary strictures can be categorized according to technical factor as anastomotic or nonanastomotic strictures. Biliary anastomotic stricture is a common complication after living-donor liver transplantation, occasionally causing deaths. The two most commonly used methods for biliary anastomosis are duct-to-duct anas...

journal_title：Journal of gastroenterology and hepatology

authors： Chok KS,Lo CM

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Distinguishing Crohn's disease (CD) from intestinal tuberculosis (ITB) is a clinical challenge. This meta-analysis assessed the clinical usefulness of Interferon-gamma releasing assay (IGRA) and anti-Saccharomyces cerevisiae antibody (ASCA) in the diagnosis of ITB and CD, respectively. METHODS:Syst...

journal_title：Journal of gastroenterology and hepatology

authors： Ng SC,Hirai HW,Tsoi KK,Wong SH,Chan FK,Sung JJ,Wu JC

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND AIM:Covered metallic stents (CMSs) were developed to overcome tumor ingrowth in uncovered metallic stents (UMSs) for malignant biliary obstruction, but superiority of CMSs over UMSs is still controversial due to the high migration rate in CMS. Therefore, we conducted this retrospective analysis to clarif...

journal_title：Journal of gastroenterology and hepatology

authors： Nakai Y,Isayama H,Kogure H,Hamada T,Togawa O,Ito Y,Matsubara S,Arizumi T,Yagioka H,Mizuno S,Sasaki T,Yamamoto N,Hirano K,Tada M,Koike K

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND AIM:Safety and efficacy data on endoscopic treatment of duodenal neoplasm are limited. We suggest the technical feasibility of endoscopic procedures by evaluating the results of endoscopic treatment for nonampullary duodenal adenoma and adenocarcinoma. METHODS:Forty-five patients who underwent endoscopi...

journal_title：Journal of gastroenterology and hepatology

authors： Seo JY,Hong SJ,Han JP,Jang HY,Myung YS,Kim C,Lee YN,Ko BM

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND AIM:In general, the spleen is one of the abdominal organs connected by the portal system, and a splenectomy improves hepatic functions in the settings of partial hepatectomy (Hx) for portal hypertensive cases or living donor liver transplantation with excessive portal vein flow. Those precise mechanisms ...

journal_title：Journal of gastroenterology and hepatology

authors： Arakawa Y,Shimada M,Utsunomiya T,Imura S,Morine Y,Ikemoto T,Mori H,Kanamoto M,Iwahashi S,Saito Y,Takasu C

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND AIM:To investigate the effectiveness of peroral endoscopic myotomy (POEM) surgery in achalasia patients with failure of prior pneumatic dilation (PD). METHODS:Twenty-one patients with a history of failed PD were prospectively recruited as the case group, and 30 patients with no history of prior treatmen...

journal_title：Journal of gastroenterology and hepatology

authors： Ling T,Guo H,Zou X

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND AIM:The prevalence of ulcerative colitis (UC) is increasing steadily in Japan. In Western countries, a bimodal distribution, with UC onset peaks in youth and middle age, is observed, and smoking cessation is reported as a risk factor for UC. However, there are few reports on a bimodal distribution of ons...

journal_title：Journal of gastroenterology and hepatology

authors： Takahashi H,Matsui T,Hisabe T,Hirai F,Takatsu N,Tsurumi K,Kanemitsu T,Sato Y,Kinjyo K,Yano Y,Takaki Y,Nagahama T,Yao K,Washio M

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND AIM:This study was designed to demonstrate the safety and efficacy of esomeprazole combined with flupentixol/melitracen for the treatment of gastroesophageal reflux disease (GERD) patients with emotional disorders. METHODS Two hundred eighty-nine GERD patients with emotional disorders were divided random...

journal_title：Journal of gastroenterology and hepatology

authors： Yu YY,Fang DC,Fan LL,Chang H,Wu ZL,Cao Y,Lan CH

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of this study is to evaluate the association of the regulatory T cells (Treg)/T-helper (Th) 17 cells and transforming growth factor-β1 (TGF-β1)/interleukin-17 (IL-17) ratios with the survival and disease progression in patients with hepatitis B virus (HBV)-associated liver cirrhosis (LC). ME...

journal_title：Journal of gastroenterology and hepatology

authors： Yu X,Guo R,Ming D,Su M,Lin C,Deng Y,Lin Z,Su Z

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Hepatic steatosis is a metabolic liver disease with the potential to progress to steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC). The aim of this study was to investigate the impact of CCAAT/enhancer-binding protein homologous protein (CHOP) deficiency in the development of steatosis-...

journal_title：Journal of gastroenterology and hepatology

authors： Toriguchi K,Hatano E,Tanabe K,Takemoto K,Nakamura K,Koyama Y,Seo S,Taura K,Uemoto S

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND AIM:The presence of spur-cell anemia (SCA) is due to lipid disturbances of the erythrocyte membrane and may develop in patients with advanced liver cirrhosis. The accurate predicting value of SC for survival has not been clarified. The aim of this study was to evaluate SCA as a prognostic indicator in pa...

journal_title：Journal of gastroenterology and hepatology

authors： Alexopoulou A,Vasilieva L,Kanellopoulou T,Pouriki S,Soultati A,Dourakis SP

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND AIM:This study sought to investigate the effects of hypothermia induced by adenosine 5'-monophosphate (5'-AMP) on L-arginine (L-Arg)-induced acute pancreatitis in rats. METHODS:The rats were divided into four groups: the control group, the acute pancreatitis group, the 5'-AMP pretreatment group, and the...

journal_title：Journal of gastroenterology and hepatology

authors： Wang Y,Guo W,Li Y,Pan X,Lv W,Cui L,Li C,Wang Y,Yan S,Zhang J,Liu B

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND AIM:Multi-detector-row computed tomography (MDCT) has been reported to be a potentially useful modality for detection of the bleeding origin in patients with acute upper massive gastrointestinal (GI) bleeding. The purpose of this study is to investigate the efficacy of MDCT as a routine method for detect...

journal_title：Journal of gastroenterology and hepatology

authors： Miyaoka Y,Amano Y,Ueno S,Izumi D,Mikami H,Yazaki T,Okimoto E,Sonoyama T,Ito S,Fujishiro H,Kohge N,Imaoka T

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND AIM:Recent studies have shown that imbalance between tumor-infiltrating interleukin (IL)-17(+) T cells and regulatory T cells (Tregs) is an important regulator of progression in various cancers, but little is known regarding this imbalance in hepatocellular carcinoma (HCC). This study explored the role o...

journal_title：Journal of gastroenterology and hepatology

authors： Huang Y,Wang F,Wang Y,Zhu Z,Gao Y,Ma Z,Xu R,Du Z

更新日期：2014-04-01 00:00:00

abstract：:Coffee is one of the most popular beverages in the world. Several studies consistently show that coffee drinkers with chronic liver disease have a reduced risk of cirrhosis and a lower incidence of hepatocellular carcinoma regardless of primary etiology. With the increasing prevalence of non-alcoholic fatty liver dise...

journal_title：Journal of gastroenterology and hepatology

authors： Chen S,Teoh NC,Chitturi S,Farrell GC

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND AND AIM:This study aimed to investigate the prognostic value of expression of hepatocyte nuclear factors (HNFs) involved in hepatic gene transcription in patients undergoing curative resection for hepatocellular carcinoma (HCC). METHODS:We performed immunohistochemical analyses on microarrays of the tumors ...

journal_title：Journal of gastroenterology and hepatology

authors： Shim JH,Kang HJ,Han S,Lee YJ,Lee SG,Yu E,Lee HC

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND AND AIM:After selective biliary access following precut fistulotomy in difficult biliary cannulations (DBC), there are several methods of completely opening the remaining papillary roof for the removal of biliary stones. We evaluated the efficacy of one-step transfistula balloon dilation following fistulotom...

journal_title：Journal of gastroenterology and hepatology

authors： Jun BG,Lee TH,Jeong S,Hwang JC,Yang MJ,Song TJ,Choi HJ,Moon JH,Park SH

更新日期：2014-01-01 00:00:00

abstract：:The Korean College of Helicobacter and Upper Gastrointestinal Research first developed guidelines for the diagnosis and treatment of Helicobacter pylori (H. pylori) infection in 1998, and revised guidelines were proposed in 2009 by the same group. Although the revised guidelines were based on a comprehensive review of...

journal_title：Journal of gastroenterology and hepatology

authors： Kim SG,Jung HK,Lee HL,Jang JY,Lee H,Kim CG,Shin WG,Shin ES,Lee YC,Korean College of Helicobacter and Upper Gastrointestinal Research.

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND AIM:Nonalcoholic fatty liver disease (NAFLD) is becoming an increasingly important health issue. However, there are no data on the change in prevalence of NAFLD within a population over time, especially in the mainland of China. The goal of this study was to estimate the pooled prevalence of NAFLD in the...

journal_title：Journal of gastroenterology and hepatology

authors： Li Z,Xue J,Chen P,Chen L,Yan S,Liu L

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND AIM:Fecal calprotectin (FC) has become a reliable biomarker for intestinal inflammation in inflammatory bowel diseases (IBDs). However, a simple and rapid assay to replace conventional ELISA is necessary for wider use in clinical practice. In this study, we investigated the usefulness of a novel method f...

journal_title：Journal of gastroenterology and hepatology

authors： Inoue K,Aomatsu T,Yoden A,Okuhira T,Kaji E,Tamai H

更新日期：2014-01-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum ranging from simple steatosis to non-alcoholic steatohepatitis, which causes an increased risk of cirrhosis, type 2 diabetes, and cardiovascular complications. With the worldwide growing incidence of obesity, sedentary lifestyle, and unhealthy dietary pa...

journal_title：Journal of gastroenterology and hepatology

authors： Fan JG,Cao HX

更新日期：2013-12-01 00:00:00

abstract：:Fatty acids in our daily diet are broadly classified into cis and trans fatty acids (TFAs). TFAs are formed during the manufacturing process of hydrogenated vegetable oils such as margarine. Modern diets such as deep-fried products, frozen foods, and packaged snacks commonly include large quantities of margarine conta...

journal_title：Journal of gastroenterology and hepatology

authors： Okada Y,Tsuzuki Y,Ueda T,Hozumi H,Sato S,Hokari R,Kurihara C,Watanabe C,Tomita K,Komoto S,Kawaguchi A,Nagao S,Miura S

更新日期：2013-12-01 00:00:00